About: holmes

Website

http://cneuro.zool.ohiou.edu/holmes/

Profile

Current work focuses on the development of mathematical and computational models of individual neurons of the hippocampus that will be appropriate for use in network models to explore hippocampal function. The immediate focus is to develop models of CA1 pyramidal cells that describe how computation and synaptic modification occur in these cells. Work is done in collaboration with Larry Grover at Marshall University School of Medicine and Jose Ambros-Ingerson here at Ohio University. Models are done on three different levels: the molecular level, the synapse level, and the neuron level. Simulations are done with GENESIS, NEURON, and with code written specifically for a particular model.